Vayne is one of the best scaling bot laners in League of Legends season 10. She has a weak early game, but once she gets going, she becomes unstoppable. After you buy Blade of the Ruined King, you will kill tanks and carries alike with no issues.
Runes
Precision
Press the Attack: This keystone ensure that you get good trades early on and are able to three-shot carries in the mid to late-game. The keystone is easily activated with a simple auto, Q, auto combo ensuring a huge amount of damage without issues.
Triumph: Triumph allows you to do those montage plays. It recovers a portion of your health on a takedown while also giving you some additional gold.
Legend: Alacrity This is a pretty basic rune to grant you more attack speed, which is a core stat for Vayne. But if you’re going to face a lot of beefy champions, feel free to take Legend: Bloodline to increase your lifesteal potential.
Cut Down: This rune helps you penetrate the beefy frontline even easier. Since you aren’t going to build any health items, this item will be able to be activated quite often against tank champions. If no tank champions are present on the opposing team, however, then feel free to take Coup de Grace instead to deal more damage to those low-health enemies.
Sorcery
Nimbus Cloak: This rune became broken overnight once people realized how efficient the extra movement speed is, especially during the laning phase. From being barely picked to picked by most champions in the game, this rune ensures you get a small ghost effect when you use any summoner spell.
Gathering Storm: Gathering Storm is a straightforward scaling rune to increase your damage output the longer the game goes.
Bonuses: +10-percent attack speed, +9 adaptive force, +6 armor
Starting items
Doran’s Blade
Having some early lifesteal and attack damage is crucial for Vayne. Doran’s Blade also grants you 80 bonus health to make you a tad bit tankier early on. This item can be purchased multiple times if you’re having early game issues and need power as soon as possible.
Health Potion
During the farming phase, you are going to take damage from the enemy champions. Health potions heal back 150 health over 15 seconds and will give you extra time before having to base.
Core items
Blade of the Ruined King
Blade of the Ruined King is the tank-killer item and is a must-have if you want to take down enemy tanks. This is the perfect item for Vayne, which syncs up well with her W and ensures you deal a lot of on-hit damage regardless of how much AD you have.
Guinsoo’s Rageblade
Guinsoo’s can be one of the most broken items in the game on champions who have on-hit mechanics. Vayne has true damage in her W and Guinsoo’s allows her to use it more often, melting down tanks with no issues in the span of a couple of seconds. While the basic statline feels lackluster, the Guinsoo’s Rage effect gives you additional attack speed and the repeat on-hit effect makes up for those weak base stats of the item.
Berserker’s Greaves
Berserker’s are core boots for Vayne, rushable as a first item before you get any other items. It gives you movement speed to move faster in the laning phase and act like a ninja in teamfights with swift moves. The attack speed is also very valuable, especially due to your W which deals true damage.